Plasma renin activity and excretion of water and electrolytes in stroke-prone SHR rats.

نویسندگان

  • K Kawashima
  • K Shiono
  • H Sokabe
چکیده

The elevated levels of plasma renin activity (PRA) in stroke-prone SHR rats (SHRSP) at several months of age were reported by Matsunaga et al (Jap Circulat J 39: 1305, 1975) and Morita and Okamoto (Jap Heart J 18: 573, 1977). Matsunaga et al (Jap Circulat J 40: 889, 1976) divided SHRSP into 2 groups on the basis of water turnover: one had significantly higher water intake and urine volume than the other. In the present study, blood pressure (BP), PRA, water, and electrolytes excretion were determined in SHRSP and compared with those in stroke-resistant SHR rats (SHRSR) and Wistar-Kyoto rats (WKY).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Renin-angiotensin system in severe hypertension of stroke-prone SHR rats.

It has been reported that either hypertension or onset of stroke of stroke-prone SHR(SHRSP) rats is accelerated by salt-loading. The present study was designed to investigate the participation of renin-angiotensin system in maintenance of saltaccelerated severe hypertension in male SHRSP rats. Animals were kept on a standard laboratory chow and loaded with 1% NaCl solution as drinking water fro...

متن کامل

[A study on the effects of a Mg-deficient diet on blood pressure and various hormonal systems in Wistar rats and spontaneously hypertensive rats].

The influence of a Mg-deficient diet on blood pressure and various hormonal systems was examined in Wistar rats (WR) and spontaneously hypertensive rats (SHR). The WR and SHR were individually divided into 2 groups. The Mg-deficient diet was given to one group, and a Mg-containing diet was given to the other group for 3 weeks. During this experimental period, the body weight, blood pressure, ur...

متن کامل

Antirenin immunization versus angiotensin converting enzyme inhibition in rats.

The effects of specific active immunization against renin were compared with those of chronic angiotensin converting enzyme (ACE) inhibition. Male spontaneously hypertensive rats (SHR) were immunized (SHR-I) (n = 10) against pure murine renin (four injections of 30 micrograms/kg s.c.) or received (SHR-P) (n = 11) a converting enzyme inhibitor (perindopril, 2 mg/kg/day per os for 4 weeks). Sham-...

متن کامل

Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats.

We recently showed that brain mineralocorticoid receptors (MRs) are involved in blood pressure and kidney function control in normotensive Wistar rats. We now assessed the involvement of brain MRs in spontaneously hypertensive rats (SHR), in which the presence of adrenocorticoids has been shown to be required for the development of hypertension. The effect of a single intracerebroventricular (I...

متن کامل

Lacidipine prevents endothelial dysfunction in salt-loaded stroke-prone hypertensive rats.

Endothelium-dependent vasorelaxation is defective in hypertensive rats, especially in conduit arteries. In the stroke-prone spontaneously hypertensive rat, impaired endothelium-dependent vasorelaxation appears to contribute to the pathogenesis of stroke independent of blood pressure. Because treatment with lacidipine, a long-acting calcium channel blocker, protects against stroke and cardiovasc...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Japanese heart journal

دوره 19 4  شماره 

صفحات  -

تاریخ انتشار 1978